• Actives absorb through the skin - For targeted fat loss

• Powerful alkaloids enhance fat release from stubborn adipose tissue

• Raspberry Ketone and Evodiamine catalyze the fat burning action

• Bio-identical hormones DHEA & 7-oxo DHEA increase the rate of fat loss

• Anti-catabolic ingredients protect muscle, while encouraging fat oxidation

What is DermaTherm?

DermaTherm is a topical cream that targets and dissolves fat upon the site of application. The formula dries within minutes, leaving the skin clean and moisturized. At the recommended dose, DermaTherm will last 25 days.

Dropping body fat can be as simple as reducing carbohydrates, increasing protein while putting yourself in an overall calorie deficit. However, even with the perfect diet and exercise program, there are certain areas of the body that "hold on" to fat tissue no matter how much weight or body fat you lose - and this is where DermaTherm offers a distinct advantage - it targets and releases stubborn body fat, converting it to usable energy.

Oftentimes, going on low calorie diet also triggers cortisol levels to rise, causing a consequential breakdown of muscle (amino acids) for glycogen and energy, leaving you soft and deflated. A welcome benefit of DermaTherm is its ability to spare muscle by blocking the breakdown action of cortisol on muscle mass. (25-27)

DermaTherm offers the clear advantage of allowing you to diet, while encouraging the breakdown of fat and keeping your muscle intact. It's the secret weapon for becoming lean, hard and chiseled.

How does DermaTherm "target"�fat loss?

DermaTherm accomplishes a targeted action by delivering the small, light weight ingredients deep within the adipose tissue via our OHV topical delivery system.

The targeted dissolution of fat is accomplished by delivering the active ingredients through the skin and directly into the fat cells where they can oxidize and dissolve "stubborn" fat tissue.

How does DermaTherm "dissolve"�fat tissue?

The term "dissolve" refers to the breakdown of fat by lipase, which is the most important step in burning off body fat. In order for the body to use fat as an energy source, the fat must be broken down to simple fatty acids. (6) This process is known as lipolysis, and DermaTherm increases lipolysis by increasing lipase activity, and the breakdown of fat. Thus, DermaTherm helps "dissolve"�stored fat. Once the fat tissue is "dissolved"�it becomes usable energy, gets sent to the mitochondria, and gets burned off.

In other words, DermaTherm pulls fat from the fridge and puts it to the furnace.

What results should I expect with DermaTherm?

DermaTherm is designed to enhance the rate of fat loss in site specific areas, thus offering an easy way to fine-tune your physique.*

When incorporated with a well planned diet & exercise program, DermaTherm will offer the following benefits -

• Increased muscular definition
• Harder & more vascular looking physique
• Improved tone and tightness of flabby areas

One effect that has also been reported is an increase in body heat and perspiration, from the thermogenic ingredients and increased metabolic activity - ensuring you that DermaTherm is doing what it should.

* Clinical human studies have shown that maximum results may take up to 12 weeks to realize.* (8,9) Best results are obtained when calories are restricted and below normal maintenance levels.

What are the ingredients, and how does it work?

The first ingredient that increases lipase activity is a naturally occurring alkaloid known as theophylline which has been proven to be an effective "spot reducer" in several human studies. (5,8-11) On a cellular level, theophylline increases lipase activity by stimulating cAMP (cyclic adenosine monophosphate), causing downstream activation of protein kinase A, resulting in a subsequent increase in lipase activity at the adipocyte (fat cell). (1-5) Remember, lipase is the fat dissolving enzyme required to breakdown fat, so it can truly be burned off.

Raspberry ketone is another ingredient proven to assist in lipolysis. (7) More specifically, Raspberry ketone increases the transport of lipase from the cytosol to the lipid droplets in the fat cell - putting it right where it needs to be to dissolve fat tissue. (7)

The next ingredient which further catalyzes the lipase response is evoidamine. This alkaloid from the Evodia Fruit has been shown to be a powerful inducer of "lipolytic activity" by dramatically increasing the lipase activity from norepinephrine stimulation. (12) Evodiamine also contributes to fat loss by increasing insulin sensitivity. By increasing insulin sensitivity, you can potentially reduce circulating insulin levels, and intensify lipase activity. You see, insulin is a major suppressor of lipolysis because it is a "storage"� hormone that wants to store bodyfat, not release it. Therefore reducing circulating insulin levels will encourage lipolytic activity, and therefore increase the release of fatty acids to be burned off as energy (the main reason low-carb diets are so effective).

Trans-cinnamaldehyde is another ingredient that dramatically increases insulin sensitivity (13-17). Again, increasing insulin sensitivity can reduce circulating insulin levels, which will initiate the lipolytic process.Trans-cinnamaldehyde is aromatic molecule extracted from cinnamon, which also happens to be a powerful vasodilator for increasing permeation of actives ingredients through the skin. (18-19)

The final active ingredients are the bio-identical hormones DHEA & 7-oxo-DHEA. Both of these hormones are included for their powerful effects on catalyzing oxidation of fatty acids by increasing glycerol-3-phosphate and mitochondrial malic enzyme activity. (20,21) Human research has proven these hormones to triple the rate of fat loss by increasing the metabolic activity and thermogensis through the aforementioned mechanism. (22-24)

Does DermaTherm have any side effects?

At the recommended dose, DermaTherm is safe for men and women. Because the active stimulants in DermaTherm are primarily active at the site of application, typical side-effects such as anxiety, heart palpitations, and insomnia are rare. However, it is still recommended that the product only be used early in the day and not within 8 hours of bedtime.

Note: DermaTherm may leave the skin warm, red or slightly tingly for approximately 30-40 minutes after application.

References -

1. Activation of Hormone-Sensitive Lipase and Phosphorylase Kinase by Purified Cyclic GMP-Dependent Protein Kinase
John C et al.
PNAS | November 1, 1977 vol. 74 no. 11 4843-4847

2. Effect of phosphodiesterase inhibition with amrinone or theophylline or lipolysis and blood flow in human adipose tissue in vivo as measured with microdialysis
P Arner, et al.
J. Lipid Res., Oct 1993; 34: 1737.

3. Acute adaptation in adrenergic control of lipolysis during physical exercise in humans.
Wahrenberg H, et al.
Am J Physiol. 1987 Oct;253(4 Pt 1):E383-90.

4. Adrenergic lipolysis in human fat cells: properties and physiological role of alpha-adrenergic receptors
Berlan M, et al.
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5. Fat cell lipolysis induced by theophylline in obese subjects before and after caloric restriction
G Chiodini, et al
Arch Maragliano Patol Clin, Jan 1979; 35: 7-11.

6. Adipose tissue lipase. In: Borgstro¨m, B., Brockman, H.L. (Eds.) Lipase
Belfrage, P et al
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7. Anti-obese action of raspberry ketone.
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Life Sci, May 27, 2005; 77(2): 194-204

8. Topical Fat Reduction
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9. Topical fat reduction from the waist.
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10. Enhancement of transdermal delivery of theophylline using microemulsion vehicle.
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11. Fat reduction by topical waist applications may actually work.
GD Lundberg
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12. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.
Kobayashi,Y. et al.
Planta Med., 67, 628 - 633.(2001)

13. Cinnamon improves glucose and lipids of people with type 2 diabetes.
Khan A, et al.
Diabetes Care. 2003;26:3215 - 8.

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Phytomedicine, Jan 2007; 14(1): 15-22.

15. Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene
Mounib Elchebly, et al
Science, Mar 1999; 283: 1544.

16. Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases.
H Fu, J Park, et al.
Biochemistry, Aug 2002; 41(34): 10700-9.

17. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signaling.
Anderson, et al.
Horm Res, September 1, 1998; 50(3): 177-82.

18. Pharmacological studies on Chinese cinnamon. V. Catecholamine releasing effect of cinnamaldehyde in dogs.
M Harada, et al.
J Pharmacobiodyn, August 1, 1982; 5(8): 539-46.

19. Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro.
H Weibel et al.
Contact Dermatitis, March 1, 1989; 20(3): 167-72

20. The effect of ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis.
BOBYLEVA V, et al.
Arch Biochem Biophys 341: 122-128, 1997.

21. DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats.
RYU JW, et al.
Biochim Biophys Res Commun 303: 726-731, 2003.

22. A randomized, double blind, placebo controlled study of 3 - acetyl - 7 - oxo - dehydroepiandrosterone in healthy overweight adults.
Kalman, D., et al
Curr. Ther. Res. 61, 435 - 442. (2000)

23. The effect of 7 - keto Naturalean on weight loss: A randomized, double blind placebo controlled trial.
Zenk, J, et al.
Curr. Ther. Res. 63, 263 - 272. (2002)

24. Ergosteroids: Induction of Thermogenic Enzymes in Liver of Rats Treated with Steroids Derived from Dehydroepiandrosterone.
H Lardy, et al.
PNAS, Jul 1995; 92: 6617

25. 7 beta-OH-DHEA counteracts dexamethasone induced suppression of primary immune response in murine spleenocytes.
Sterzl, I., et al
J. Ster. Biochem. Mol. Biol. 71, 133 - 137. (1999)

26. Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?
B Robinzon, et al.
Arch Biochem Biophys, Apr 2003; 412(2): 251-8.

27. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice.
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Steroid Biochem Mol Biol, Jul 1994; 50(1-2): 91-100.