• DHEA & Pregnenolone hormone formula
• Enhances athletic performance, recovery and strength
• Resveratrol & 7,8-Benzoflavone prevent estrogenic side effects
• Increases GH & IGF-1 to support muscle growth and fat reduction
• Pregnenolone provides hair-loss protection

Select the Science tab above for details on the benefits of Dermacrine DHEA to increase libido and support fat loss.

It's in the Science!

What is Dermacrine Liqua-Vade?

Dermacrine Liqua-Vade is an orally active male pro-hormone formula that boosts male hormone levels. This enhances performance, reduces body fat, and increases lean muscle. At the standard dose, Dermacrine will last 4 weeks.

Dermacrine is a complete hormonal optimization formula which contains balanced levels of active bio-identical hormones and natural anti-estrogens. These delicate active ingredients are delivered by Primordial Performance's pharmaceutical grade Liqua-Vade delivery system. 

Pushing past plateaus and encouraging new muscular growth requires high levels of anabolic & androgenic hormones. By supplying the body with high amounts of pro-hormones (aka,  hormone precursors), Dermacrine dramatically increases the body's anabolic and androgenic activity. This "hormonal edge" becomes noticeable within minutes of dosing, fueling the body with the high-octane, adrenaline-pumping, rock-crushing power that raises performance to a new level.

What are anabolic & androgenic hormones?

Anabolic means stimulation of growth, as in muscle growth. Androgenic means stimulation of male characteristics such as sex drive, strength, and aggression. Testosterone is a perfect example of a hormone that possesses anabolic & androgenic properties.

Unknown to most, are the "other" naturally occurring hormones that have strong anabolic & androgenic properties - just like Testosterone. For instance, androstenediol and androstenedione both have anabolic & androgenic activity that supports muscle growth, fat loss, and muscular strength. Dermacrine not only boosts testosterone, but it also boosts these other male hormones. (1,2)

What are the ingredients and how do they work?

The primary hormone in Dermacrine is DHEA (dehydroepiandrosterone) - the precursor to all anabolic/andrognic hormones in the body. (1)

Although DHEA has been available for years, and is found in many other hormonal supplements, Dermacrine with Liqua-Vade technology offers a distinct advantage that makes it up to 20x more effective than regular pill or tablet based products. You see, with the rapidly absorbing Liqua-Vade technology, Dermacrine delivers DHEA to the blood stream within seconds. Within minutes, the body begins converting DHEA to other more anabolic hormones such as androstenediol, androstenedione and testosterone. This is where Dermacrine gets it's anabolic & androgenic horsepower - for increasing strength and lean muscle beyond your natural limit.

The DHEA is also converted to more powerful fat burning hormones such as 7-oxo-DHEA and 7-beta-DHEA. (5) These are powerful thermogenic hormones that increase the rate of fat loss, helping you shed fat as you gain muscle. (12-17) 

The second hormone in Dermacrine is pregnenolone. This hormone was added in a precise ratio with the DHEA to balance and control conversion to DHT (dihydrotestosterone), which may cause hair loss in men prone to androgenic alopecia. (24) Those sensitive to DHT who are concerned with hair-loss need not worry; Dermacrine won't cost you the hair-line! Pregnenolone is also a powerful neurosteroid, which can enhance cognitive focus and memory. (21-23)

Since certain anabolic & androgenic hormones can convert to estrogen, Dermacrine was fortified with an anti-estrogen complex which consists of resveratrol, 7,8 benzoflavone and chrysin. These are natural plant based compounds that block estrogenic effects such as gyno and fat storage. (25-33) Resveratrol, 7,8 benzoflavone and chrysin have also been proven to have potent fertility stimulating properties, which can help promote increased sexual desire, erectile function and stamina. (25-33)

What sort of results should I notice with Dermacrine?

Within the first couple days the following results should become noticeable - (20,23,37)

• Increased motivational energy
• Improved cognitive focus & drive 
• Improved libido & sexual performance

Within 2-3 weeks users start to notice - (35,38-40)

• Enhanced strength during training
• Increased stamina in the gym & bedroom
• Faster recovery time (35,38-40)
• Aggressive increase in appetite
• Better sleep quality
• Improvements in generally well-being (34,36,37)

Even without changes in diet or exercise Dermacrine will cause an improvement in body composition of a 2-3 lb loss in fat with a 2-3 lb gain in lean muscle within a 4-6 week period. This shift in body composition is most noticeable when proper "pre" and "post" measurements are taken. As with any muscle building product, best results are obtained when combined with high protein intake, heavy weight training and sufficient rest.

Also, see our collection of in-house hormone analyses from three men of different ages* -

22 year old tester
31 year old tester
44 year old tester

*Results are from the original topical Dermacrine. (new results are currently underway for Dermacrine Liqua-Vade)

How long can I use Dermacrine? Do I have to take time off?

Since Dermacrine supplies the body with an outside source of hormones and causes such a significant boost in hormone levels, it can eventually suppress the body's natural hormone production. Therefore, it is recommended that Dermacrine be cycled to avoid inhibition.*

We recommend using Dermacrine for 4 weeks at a time, with at least 4 weeks off between each cycle. 6-8 week cycles with Dermacrine are safe, however if you choose to use Dermacrine for longer than 4 weeks we recommend you consider post cycle therapy (PCT) after the cycle to ensure quick and full recovery of natural testosterone production.

For more information about PCT, please visit The Official PCT Thread.

* Men on long-term hormone or testosterone replacement therapy (HRT/TRT) may use Dermacrine indefinitely with their hormonal regimen since shutdown of natural testosterone production is generally acceptable.

Are there any side effects?

Dermacrine should not be used by anyone under the age of 18.

Aside from the above mentioned suppression of your body's hormone production, using Dermacrine within the recommend dose is safe for men, granted there are no serious pre-existing medical conditions. The only side-effects to consider could possibly be irritability or semi-anxiety which is generally avoidable if the user is participating in vigorous physical activity on a daily basis.

Why should I choose Dermacrine over other pro-hormones?

As explained earlier, Dermacrine is more effective than other pill or tablet DHEA supplements because it delivers DHEA with our advanced Liqua-Vade delivery system. 

Unlike other orally active pro-hormones or pro-steroids, Dermacrine does not stress the liver, prostate or cholesterol levels. Dermacrine will also not cause the typical side effects of lethargy or appetite suppression because of toxic effects. The hormones in Dermacrine are non-toxic and naturally occurring in the human body.

Dermacrine Liqua-Vade can be dosed several different ways -

1. Sex Steroid Metabolism in Human Peripheral Blood Mononuclear Cells Changes with Aging 

The Journal of Clinical Endocrinology & Metabolism 90(11):6283-6289 (2005)

2. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. 
Schmidt M, et al.
J Endocrinol. 2000 Feb;164(2):161-9.

3. High bioavailability of dehydroepiandrosterone administered percutaneously in the rat 
C Labrie, et al. 
Sep 1996; 150: S107 - S118.

4. Effects of transdermal application of DHEA to men on the levels of steroids, gonadotropins and lipids. 
SULCOV� J, et al.
Physiol Res 49: 685-693, 2000.

5. Transformation in vitro of [4-14C ] dehydroepiandrosterone into 7-oxygenated derivatives by the normal human male and female skin tissue. 
Faredin, I., et al.
J. Invest. Dermatol. 52:357. 1969

6. The metabolism of [4-14C] 5 androstene-3P, 17P-diol by normal human skin in vitro. 
Faredin, et al. 
Acta Med. Acad. Sci. Hung. 32:139. 1975.

7. Sebocytes are the key regulators of androgen homeostasis in human skin. 
M Fritsch, et al.
J Invest Dermatol, May 1, 2001; 116(5): 793-800.

8. Transformation and conjugation of dehydroepiandrosterone by human skin. 
Berliner, D. L., et al. 
J. Clin. Endocrinol. 27:1214. 1967.

9. The formation of water soluble steroids by human skin. 
Berliner, D. L., et al.
J. Invest. Dermatol. 50:220. 1968

10. The in vitro metabolism of dehydroepiandrosterone in human skin. 
I Faredin, et al. 
Acta Med Acad Sci Hung, Jan 1967; 23(2): 169-79.

11. The metabolism of [4-14C] dehydroepiandrosterone by human skin in vitro. I. Transformation in vitro of [4-14C] dehydroepiandrosterone into Androst-4-ene-3,17-dione, testosterone and androsterone by normal human male and female skin slices. 
I Faredin, et al. 
Acta Med Acad Sci Hung, Jan 1970; 27(1): 95-102.

12. Ergosteroids: Induction of Thermogenic Enzymes in Liver of Rats Treated with Steroids Derived from Dehydroepiandrosterone.
H Lardy, et al. 
PNAS, Jul 1995; 92: 6617

13. Ergosteroids VI. Metabolism of dehydroepiandrosterone by rat liver in vitro: A liquid chromatographic mass spectrometric study.
Marwah, A., et al. 
J. Chromatog. (2002). B 767, 285-299.

14. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone.
LARDY H, et al. 
Proc Natl Acad Sci USA 92: 6617-6619, 1995.

15. A randomized, double blind, placebo controlled study of 3 - acetyl - 7 - oxo - dehydroepiandrosterone in healthy overweight adults. 
Kalman, D., et al. 
(2000). Curr. Ther. Res. 61, 435-442.

16. The effect of 7 - keto Naturalean on weight loss: A randomized, double blind placebo controlled trial. Zenk, J., et al. 
(2002). Curr. Ther. Res. 63, 263-272.

17. How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influence thyroid function.
R Hampl, et al. 
Physiol Res, Jan 2006; 55(1): 49-54.

18. DHEA treatment for HIVþ patients: Effects on mood, androgenic and anabolic parameters. 
Rabkin, J., et al. 
Psychoneuro endocrinology. R. 25, 53-68. 2000

19. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men. 
Khorram O, et al.
J Gerontol 1997; 52A:M1- M7.

20. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. 
Casson PR, et al. 
Am J Obstet Gynecol. 169:1536-1539. 1993

21. Novel brain function: biosynthesis and actions of neurosteroids in neurons. 
K Tsutsui, et al. 
Neurosci Res, Apr 2000; 36(4): 261-73.

22. Individual differences in cognitive aging: implication of pregnenolone sulfate. 
W Mayo, et a. 
Prog Neurobiol, September 1, 2003; 71(1): 43-8.

23. Memory-Enhancing Effects in Male Mice of Pregnenolone and Steroids Metabolically Derived from it. 
JF Flood, et a. 
PNAS, Mar 1992; 89: 1567.

24. Steroid 5alpha-reductase inhibitors.
E Flores, et al.
Mini Rev Med Chem, May 1, 2003; 3(3): 225-37

25. Die Bedeutung der Passionsblume in der Heilkunde. 
Lutomski J et al.
Pharmazie in unserer Zeit 1981;10:45-49.

26. The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies.
Tyler VE et al.
Pharmaceutical Products Press, New York, 1993.

27. Drug/substance reversal effects of a novel trisubstituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn. -a brief perspective
KAMALDEEP DHAWAN et al.
Addiction Biology (December 2003) 8, 379 - 386

28. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats.
K Dhawan and et al. 
Life Sci, Nov 2002; 71(26): 3059-69.

29. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.
Kao YC, et al.
Environ Health Perspect 1998;106:85-92

30. Inhibition of human estrogen synthetase (aromatase) by flavones
JT Kellis, Jr et al.
Science, Sep 1984; 225: 1032 - 1034.

31. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells
Yun Wang, et al.
Toxicol. Sci., Jul 2006; 92: 71 - 77.

32. trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats M. Emà lia Juan, et al.
J. Nutr., Apr 2005; 135: 757 - 760

33. trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo.
S Shin, et al.
Arch Pharm Res, Jan 2008; 31(1): 83-7.

34. An open- label dose- escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. 
Dyner TS, et al
J Acquir Immune Deficiency Syndrom 1993;6:459- 465.

35. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. Morales AJ, et al.
J Clin Endocrinol Me tab 1994;78:1360- 1367.

36. DHEA attenuates catecholamine secretion from bovine adrenal chromaffin cells. 
PS Liu et a. 
J Biomed Sci, Mar 2004; 11(2): 200-5.

37. DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range.
Friess E, et al. 
Am J Physiol 1995;268:E107-E113.

38. Anticortisols: Their Potential Usefulness.
Baulieu, et al., 
Las Vegas , NV : Conference on Cortisol and Anti-Cortisols, 1997

39. Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing. 
CC Head, et al. 
Brain Behav Immun, Nov 2006; 20(6): 590-6.

40. Androstenetriol improves survival in a rodent model of traumatic shock. 
AC Marcu, et al. 
Resuscitation, December 1, 2006; 71(3): 379-86.