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What is DermaTherm Target?
DermaTherm Target is a topical cream that targets and dissolves fat upon the site of application. The formula dries within minutes, leaving the skin clean and moisturized. At the recommended dose, DermaTherm Target will last up to 60 days.
Dropping body fat can be as simple as reducing carbohydrates, increasing protein while going into an overall calorie deficit. However, even with the perfect diet and exercise program, there are certain areas of the body that hold on to fat tissue no matter how much weight you lose - and this is where DermaTherm Target offers a distinct advantage - it targets and converts body fat to usable energy.
DermaTherm Target was designed to enhance the rate of fat loss in site specific areas, thus offering an easy way to fine-tune your physique. It's the secret weapon for turning a flat stomach in to a hard and chiseled six-pack.
How does DermaTherm Target "target" fat loss?
DermaTherm Target accomplishes a targeted action by delivering the small, light weight ingredients deep within the adipose tissue via our OHV topical delivery system.
The targeted dissolution of fat is accomplished by delivering the active ingredients through the skin and directly into the fat cells where they can oxidize and "dissolve" stubborn fat tissue.
How does DermaTherm Target "dissolve" fat tissue?
The term "dissolve" refers to the breakdown of fat by lipase, which is the most important step in burning off body fat. In order for the body to use fat as an energy source, the fat must be broken down to simple fatty acids. (6) This process is known as lipolysis, and DermaTherm Target increases lipolysis by increasing lipase activity, and the breakdown of fat.
Thus, DermaTherm Target helps dissolve stored fat. Once the fat tissue is dissolved it becomes usable energy, where it gets sent to the mitochondria, and gets burned off.
In other words, DermaTherm pulls fat from the fridge and puts it to the furnace.
What results should I expect with DermaTherm Target?
Upon the site of application, DermaTherm Target can offer the following benefits -
Note: Clinical human studies have shown that maximum results may take up to 12 weeks to realize.* (8,9) Best results are obtained when calories are restricted and below normal maintenance levels.
What are the ingredients, and how does it work?
The first ingredient that increases lipase activity is a naturally occurring alkaloid known as theophylline which has been proven to be an effective "spot reducer" in several human studies where it was shown to reduce fat tissue around the abdominal and thigh area upon topical application. (5,8-11)
On a cellular level, theophylline increases lipase activity by stimulating cAMP (cyclic adenosine monophosphate), causing downstream activation of protein kinase A, resulting in a subsequent increase in lipase activity at the adipocyte (fat cell). (1-5) Remember, lipase is the fat dissolving enzyme required to breakdown fat, so it can actually be burned off.
Raspberry ketone is another ingredient proven to assist in lipolysis. (7) More specifically, Raspberry ketone increases the transport of lipase from the cytosol to the lipid droplets in the fat cell - putting it right where it needs to be to dissolve fat tissue. (7)
The next ingredient which further catalyzes the lipase response is evoidamine. This alkaloid from the Evodia Fruit has been shown to be a powerful inducer of "lipolytic activity" by dramatically increasing the lipase activity from norepinephrine stimulation. (12) Evodiamine also contributes to fat loss by increasing insulin sensitivity. By increasing insulin sensitivity, you can potentially reduce circulating insulin levels, and intensify lipase activity. You see, insulin is a major suppressor of lipolysis because it is a "storage" hormone that wants to store bodyfat, not release it. Therefore reducing circulating insulin levels will encourage lipolytic activity, and therefore increase the release of fatty acids to be burned off as energy (the main reason low-carb diets are so effective).
Trans-cinnamaldehyde is another ingredient that dramatically increases insulin sensitivity (13-17). Again, increasing insulin sensitivity can reduce circulating insulin levels, which will initiate the lipolytic process. Trans-cinnamaldehyde is aromatic molecule extracted from cinnamon, which also happens to be a powerful vasodilator for increasing permeation of actives ingredients through the skin. (18-19)
Does DermaTherm Target have any side effects?
At the recommended dose, DermaTherm Target is safe for men and women. Because the active stimulants in DermaTherm Target are primarily active at the site of application, typical side-effects such as anxiety, heart palpitations, and insomnia are rare. However, it is still recommended that the product only be used early in the day and not within 8 hours of bedtime.
Note: DermaTherm Target may leave the skin warm, red or slightly tingly for approximately 30-40 minutes after application.
1. Administer lotion every morning, after a shower
2. Administer 1-2 pumps and apply to the skin*
3. Allow 4-5 minutes to dry
Only apply the product to clean, dry skin. Shaving off body hair is recommended, but not required. Also, avoid swimming, bathing or tanning for at least 6 hours after application.

1. Activation of Hormone-Sensitive Lipase and Phosphorylase Kinase by Purified Cyclic GMP-Dependent Protein Kinase
John C et al.
PNAS | November 1, 1977 vol. 74 no. 11 4843-4847
2. Effect of phosphodiesterase inhibition with amrinone or theophylline on lipolysis and blood flow in human adipose tissue in vivo as measured with microdialysis
P Arner, et al.
J. Lipid Res., Oct 1993; 34: 1737.
3. Acute adaptation in adrenergic control of lipolysis during physical exercise in humans.
Wahrenberg H, et al.
Am J Physiol. 1987 Oct;253(4 Pt 1):E383-90.
4. Adrenergic lipolysis in human fat cells: properties and physiological role of alpha-adrenergic receptors
Berlan M, et al.
J Physiol (Paris). 1980;76(2):133-46. French.
5. Fat cell lipolysis induced by theophylline in obese subjects before and after caloric restriction
G Chiodini, et al
Arch Maragliano Patol Clin, Jan 1979; 35: 7-11.
6. Adipose tissue lipase. In: Borgstro¨m, B., Brockman, H.L. (Eds.) Lipase
Belfrage, P et al
Elsevier, Amsterdam, pp. 365–416. (1984)
7. Anti-obese action of raspberry ketone.
C Morimoto, et al.
Life Sci, May 27, 2005; 77(2): 194-204
8. Topical Fat Reduction
Frank et al.
Obes Res. 1995;3 (Suppl 4): 561S-568S
9. Topical fat reduction from the waist.
Caruso MK, et al
Diabetes Obes Metab. 2007 May;9(3):300-3.
10. Enhancement of transdermal delivery of theophylline using microemulsion vehicle.
Zhao X, et al.
Int J Pharm. 2006 Dec 11;327(1-2):58-64. Epub 2006 Jul 21.
11. Fat reduction by topical waist applications may actually work.
GD Lundberg
Medscape J Med, Jan 2008; 10(2): 43.
12. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.
Kobayashi,Y. et al.
Planta Med., 67, 628–633.(2001)
13. Cinnamon improves glucose and lipids of people with type 2 diabetes.
Khan A, et al.
Diabetes Care. 2003;26:3215–8.
14. Cinnamaldehyde--a potential antidiabetic agent.
P Subash Babu, et al.
Phytomedicine, Jan 2007; 14(1): 15-22.
15. Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene
Mounib Elchebly, et al
Science, Mar 1999; 283: 1544.
16. Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases.
H Fu, J Park, et al.
Biochemistry, Aug 2002; 41(34): 10700-9.
17. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signaling.
Anderson, et al.
Horm Res, September 1, 1998; 50(3): 177-82.
18. Pharmacological studies on Chinese cinnamon. V. Catecholamine releasing effect of cinnamaldehyde in dogs.
M Harada, et al.
J Pharmacobiodyn, August 1, 1982; 5(8): 539-46.
19. Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro.
H Weibel et al.
Contact Dermatitis, March 1, 1989; 20(3): 167-72
20. The effect of ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis.
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Arch Biochem Biophys 341: 122-128, 1997.
21. DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats.
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Biochim Biophys Res Commun 303: 726-731, 2003.
22. A randomized, double blind, placebo controlled study of 3 - acetyl - 7 - oxo - dehydroepiandrosterone in healthy overweight adults.
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Curr. Ther. Res. 61, 435–442. (2000)
23. The effect of 7 - keto Naturalean on weight loss: A randomized, double blind placebo controlled trial.
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Distilled water, grape spirits*, aloe vera*, ethoxy diglycol, dimethyl isosorbide, safflower oil, squalene, tocopherol acetate, chamomile extract* (matricaria recutita), isopropyl myristate, green tea extract* (camellia sinensis), cetyl palmitate, sorbitan palmitate, sorbitan olivate, glyceryl stearate, PEG 100 stearate, glycerin, dimethicone, strontium nitrate, hydroxypropyl methylcellulose, tetrahydropiperine†, potassium sorbate, sodium benzoate, sodium PCA, sodium hydroxide.
* Certified Organic
† US Patent 6,849,645
Version 1
1. Administer lotion every morning, after a shower
2. Administer 1-2 pumps and apply to the skin*
3. Allow 4-5 minutes to dry
Only apply the product to clean, dry skin. Shaving off body hair is recommended, but not required. Also, avoid swimming, bathing or tanning for at least 6 hours after application.
Product may transfer to others by direct skin contact. Avoid direct skin contact with new born children. Product is not recommended for women who are pregnant or nursing, elderly, anyone under the age of 18 or anyone diagnosed with a serious health condition including but not limited to cancer, BPH, epilepsy, depression, diabetes, cardiovascular disease or high blood pressure. Always consult your physician before using this product with any over-the-counter or prescription medication.
Fast drying creamy lotion.
This product is not intended to diagnose, treat, cure, or prevent any disease.